Publication

​業績

2021

Tumurkhuu M, Batbuyan U, Yuzawa S, Munkhsaikhan Y, Batmunkh G, Nishimura W. A novel BICD2 mutation of a patient with Spinal Muscular Atrophy Lower Extremity Predominant 2. Intractable Rare Dis Res. 2021;10: 102-108. 

 

Nishimura W, Takayanagi Y, Tumurkhuu M, Zhou R, Miki H, Noda Y. Effect of long-term confinement on metabolic and physiological parameters in mice. Physiol Behav. 2021; 234: 113386.  

 

Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y. Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. JCI Insight. 2021; 6: e143791. 

2020

Udagawa H, Hiramoto M, Kawaguchi M, Uebanso T, Ohara-Imaizumi M, Nammo T, Nishimura W, Yasuda K. Characterization of taste receptor-related G-protein α-gustducin in pancreatic β-cells. J Diabetes Investig 2020; 11: 814–822 

 

2018

Nammo T, Udagawa H, Funahashi N, Kawaguchi M, Uebanso T, Hiramoto M, Nishimura W, Yasuda K. Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice. Diabetologia 2018; 61: 2608-2620 

Mochizuki S, Miki H, Zhou R, Kido Y, Nishimura W, Kikuchi M, Noda Y. Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons. Exp Cell Res 2018; 370: 601-612

Nishimura W, Sakaue-Sawano A, Takahashi S, Miyawaki A, Yasuda K, Noda Y. Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice. Islets 2018; 10: e1451282

2017

Ozawa H, Miki A, Teratani T, Shiba S, Sakura Y, Nishimura W, Noda Y, Fukushima N, Fuji H, Hozumi Y, Mukai H, Yasuda Y. Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer. Oncol Lett 2017; 13: 1731-1340

2016

Oe S, Miki H, Nishimura W, Noda Y. Mechanism of dendritic translation and localization of brain-derived neurotrophic factor. Cell Struct Funct 2016; 41: 23-31

 

2015

Nishimura W, Kapoor A, Khattabi IE, Jin W, Yasuda K, Bonner-Weir S, Sharma A. Compensatory response by late embryonic tubular epithelium to the reduction in pancreatic progenitors. PLoS ONE 2015; 10: e0142286

 

Nishimura W, Ishibashi N, Eto K, Funahashi N, Udagawa H, Miki H, Oe S, Noda Y, Yasuda K. Demethylation of the MafB promoter in a compromised β-cell model. J Mol Endocrinol 2015; 55: 31-40

 

Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell mass via epigenetic modification of Cdkn1c. Proc Natl Acad Sci USA 2015; 112: 8332-8337

 

Hiramoto M, Udagawa H, Watanabe A, Miyazawa K, Ishibashi N, Kawaguchi M, Uebanso T, Nishimura W, Nammo T, Yasuda K. Allele comparative analysis of type 2 diabetes-associated SNPs identifies allele-specific DNA-binding proteins for the KCNQ1 locus. Int J Mol Med 2015; 36: 222-230

 

Nishimura W, Takahashi S, Yasuda K. MafA is critical for maintenance of the mature beta cell phenotype in mice. Diabetologia 2015; 58: 566-574

Ohzawa H, Miki A, Hozumi Y, Miyazaki C, Sagara Y, Tanaka Y, Shiba S, Joutoku H, Sakuragi M, Takehara M, Sakuma Y, Nishimura W, Fujii H, Yasuda Y. Comparison between the antiemetic effects of palonosetron and granisetron in breast cancer patients treated with anthracycline-based regimens. Oncol Lett 2015; 9: 119-124

Nishimura W, Oishi H, Funahashi H, Fujiwara T, Takahashi S, Yasuda K. Generation and characterization of MafA-Kusabira Orange mice. Endocr J 2015; 62: 37-51

2014

Eto K, Nishimura W, Oishi H, Udagawa H, Kawaguchi M, Hiramoto M, Fujiwara T, Takahashi S, Yasuda K. MafA is required for postnatal proliferation of pancreatic β-cells. PLoS ONE 2014; 9: e104184 

2013

Nishimura W, Eto K, Miki A, Goto M, Kawaguchi M, Nammo T, Udagawa H, Hiramoto M, Shimizu Y, Okamura T, Fujiwara T, Yasuda Y, Yasuda K. Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system. Endocrinology 2013; 154: 4388-4395

Yokouchi H, Eto K, Nishimura W, Takeda N, Kaburagi Y, Yamamoto S, Yasuda K. Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells. Acta Ophthalmol 2013; 91: e289-297

2010

Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci 2010; 123: 2792-2802

Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A. OVO Homolog-like 1 (OVOl1) Transcription factor: a Novel Target of Neurogenin-3 in pancreas. Diabetologia 2010; 53: 115-122

 

2009

Nishimura W, Bonner-Weir S, Sharma A. Expression of MafA in early pancreatic progenitors is detrimental to the development of pancreas. Dev Biol 2009; 333: 108-120

 

Kondo T, Kahattabi IE, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol 2009; 23: 1281-1290

 

2008

Jiang Y, Nishimura W, Devor-Henneman D, Kusewitt D, Wang H, Holloway MP, Dohi T, Sabo E, Robinson ML, Altieri DC, Sharma A, Altura RA. Postnatal expansion of the pancreatic b-cell mass is dependent on survivin. Diabetes 2008; 57: 2718-2727

Nishimura W, Rowan S, Maas R, Bonner-Weir S, Sell SM, Sharma A. Preferential reduction of β cells derived from Pax6–MafB pathway in MafB deficient mice. Dev Biol 2008; 314: 443-456

2006

Nishimura W, Kondo T, Salameh T, Kahattabi IE, Dodge R, Bonner-Weir S, Sharma A. A switch from MafB to MafA expression accompanies differentiation to pancreatic β-cells. Dev Biol 2006; 293: 526-539

2005

Nishimura W, Salameh T, Kondo T, Sharma A. Regulation of insulin gene expression by overlapping DNA-binding elements. Biochem J 2005; 392: 181-189

2004

Hirabayashi S, Nishimura W, Iida J, Kansaku A, Kishida S, Kikuchi A, Tanaka N, Hata Y. Synaptic scaffolding molecule interacts with Axin. J Neurochem 2004; 90: 332-339

2003

Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. Oncogene 2003; 22: 8422-8431

Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. Mol Cell Biol 2003; 23: 4267-4282

Yao I, Iida J, Nishimura W, Hata Y. Synaptic localization of SAPAP1, a synaptic membrane-associated protein. Genes Cells 2003; 8: 121-129

2002

Yao I, Iida J, Nishimura W, Hata Y. Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein. J Neurosci 2002; 22: 5354-5364

Iida J, Nishimura W, Yao I, Hata Y. Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. Eur J Neurosci 2002; 15: 1493-1498

Nishimura W, Yao I, Iida J, Tanaka N, Hata Y. Interaction of synaptic scaffolding molecule and b-catenin. J Neurosci 2002; 22: 757-765

2001

Nishimura W, Naomoto Y, Hamaya K, Toda S, Miyagi K, Tanaka N. Basaloid-squamous cell carcinoma of the esophagus: diagnosis based on immunohistochemical analysis. J Gastroenterol Hepatol 2001; 16: 586-590

2000以前

Nishimura W, Iizuka T, Hirabayashi S, Tanaka N, Hata Y. Localization of BAI-associated protein1/membrane-associated guanylate kinase-1 at adherens junctions in normal rat kidney cells: polarized targeting mediated by the carboxyl-terminal PDZ domains. J Cell Physiol 2000; 185: 358-365

Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y. PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071. J Biol Chem 2000; 275: 29875-29880

Horimi T, Takasaki M, Toki A, Nishimura W, Morita S. The beneficial effect of tamoxifen therapy in patients with resected adenocarcinoma of the pancreas. Hepato-gastroenterology 1996; 43: 1225-1229